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Evidence of fetotoxicity, including delayed fetal development i. There was no evidence of teratogenicity in rats administered doses up to 1. In rabbits, anastrozole caused pregnancy failure at doses equal to or greater than 1. A multicenter, double-blind trial ATAC randomized 9, postmenopausal women with operable breast cancer to adjuvant treatment with Arimidex 1 mg daily, tamoxifen 20 mg daily, or a combination of the two treatments for five years or until recurrence of the disease. The primary endpoint of the trial was disease-free survival i. Secondary endpoints of the trial included distant disease-free survival, the incidence of contralateral breast cancer and overall survival. At a median follow-up of 33 months, the combination of Arimidex and tamoxifen did Stromba demonstrate any efficacy benefit when compared with tamoxifen in all patients as well as in the hormone receptor positive subpopulation. This treatment arm Winstrol Depot discontinued from the trial, Stromba. Based on clinical and pharmacokinetic results from the ATAC trial, tamoxifen should not be administered with anastrozole [see Drug Interactions 7. Demographic and other baseline characteristics were similar among the three treatment groups see Table 7. Breast conservation. Patients in the two monotherapy arms of the ATAC trial were treated for a median of 60 months 5 years and followed for a median of 68 months. The frequency of individual events in the intent-to-treat population and the hormone receptor-positive subpopulation are described in Table 8.




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